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Combinative Particle Size Reduction Technologies for the ...
· Nanosizing is a suitable method to enhance the dissolution rate and therefore the bioavailability of poorly soluble drugs. The success of the particle size reduction processes depends on critical factors such as the employed technology, equipment, and drug physicochemical properties. High pressure homogenization and wet bead milling are standard comminution .
Pharma Excipients | all about excipients inactive ...
· Solid self NanoEmulsifying system for the enhancement of dissolution and bioavailability of prasugrel HCl: in vitro and in vivo study. Prasugrel Hydrochloride (PHCl) is an antiplatelet drug. It is a class II drug with variable bioavailability. The objective of this work was to enhance the solubility and hence the bioavailability and efficacy ...
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Wet type microbead mill for grinding and nanoparticle dispersion, especially for dispersing nanoparticles with low crystal damage. Overview. Dual Apex Mill (DAM) is a dualaxial wet type bead mill equipped with a centrifugal bead separator and an agitating rotor, which are driven independently, with a high flexibility in the agitating rotor revolution.
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Scaleup from batch to flowthrough wet milling process ...
This work is concerned with the understanding of an undesired phenomenon often encountered during the development and scaleup of wet nanomilling processes for hydrophobic APIs .
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Mixing (process engineering)
e. In industrial process engineering, mixing is a unit operation that involves manipulation of a heterogeneous physical system with the intent to make it more homogeneous. Familiar examples include pumping of the water in a swimming pool to homogenize the water temperature, and the stirring of pancake batter to eliminate lumps (deagglomeration).
Investigation of processing time and molecule size nano ...
The current study focused on the conversion of micro alumina to nano alumina by top down approach and wet grinding process, characterization of ground particles and investigation on the effect of grinding time on the characteristics of the particles. II. MATERIALS AND METHODS Top down process is a traditional route scaling down processes acquainted in macro and micro .
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Media Milling Advances
other mills is that its power input is used directly for agitating the media to achieve grinding, not for rotating or vibrating a large, heavy tank in addition to the media. The most efficient fine grinding takes place when both impact action and shearing force are present, as illustrated in Figure 1. Wet Grinding
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